Targeting Transcription Factors with Non-Degrading Molecular Glues to Expand Therapeutic Opportunities Beyond Oncology
10:00 am - Thursday 28th January 2027
- Harnessing non-degrading molecular glues to modulate transcription factor activity through induced proximity mechanisms, creating new opportunities to access historically challenging targets
- Demonstrating how STAT6-directed molecular glues can selectively reprogram immune signalling pathways, expanding the therapeutic potential of induced-proximity medicine beyond oncology applications
- Establishing a framework for the discovery and development of non-degrading molecular glues against immunological and transcriptional targets, broadening the future scope of the molecular glue modality