Explore the Agenda
8:00 am Check-In & Light Breakfast
8:50 am Chair’s Opening Remarks
Engineering New Biological States with Non-Degrading Molecular Glues & Synthetic Regulators
9:00 am Rewiring Gene Expression with Synthetic Gene Regulators to Access Previously Undruggable Biology
- Harnessing synthetic gene regulators to induce targeted DNA-protein interactions and reprogram gene expression, expanding induced-proximity therapeutics beyond protein degradation
- Developing modular transcription-targeting platforms to selectively control disease-driving gene networks, unlocking therapeutic opportunities against previously intractable targets
- Translating synthetic gene regulation from foundational discovery to clinical development through scalable design principles and emerging therapeutic programmes, broadening the future scope of induced-proximity medicine
9:30 am Allostery Meets Induced Proximity: Creating New Pharmacological States with Non-Degrading Molecular Glues
- Leveraging molecular glues and allosteric modulators to selectively reprogram kinase signalling networks, enhancing target inhibition and unlocking synergistic therapeutic effects across oncogenic pathways
- Harnessing molecular glues to stabilize productive protein-protein interactions and activate selective cellular quality control mechanisms, expanding the biological outcomes achievable through induced proximity
- Exploring how induced protein interactions can reshape allosteric pharmacology and create new functional protein states, revealing therapeutic opportunities beyond conventional inhibition and degradation
10:00 am Targeting Transcription Factors with Non-Degrading Molecular Glues to Expand Therapeutic Opportunities Beyond Oncology
- Harnessing non-degrading molecular glues to modulate transcription factor activity through induced proximity mechanisms, creating new opportunities to access historically challenging targets
- Demonstrating how STAT6-directed molecular glues can selectively reprogram immune signalling pathways, expanding the therapeutic potential of induced-proximity medicine beyond oncology applications
- Establishing a framework for the discovery and development of non-degrading molecular glues against immunological and transcriptional targets, broadening the future scope of the molecular glue modality
10:30 am Morning Break & Networking
11:30 am Activating the Undruggable with neoCMG101 to Expand Therapeutic Opportunities Beyond Degradation
- Developing neoCMG101 as a molecular glue activator to drive targeted protein function rather than protein destruction, demonstrating the potential of glue-mediated activation strategies
- Elucidating the structural and mechanistic basis of activation to understand how induced proximity can reprogram cellular signalling, providing a framework for future activator-glue discovery
- Translating activator biology into therapeutic opportunity to address disease drivers beyond the reach of conventional degraders, broadening the molecular glue modality.
12:00 pm Expanding Molecular Glue Discovery Beyond Degradation: Identifying Transcription Factor Inhibitors Through Conformational Trapping
- Overcoming the challenge of drugging transcription factors by developing a functional E. coli screening platform to identify molecular glues that trap proteins in inactive conformations
- Moving beyond degradation by selectively preventing transcription factor DNA binding and suppressing downstream gene expression through induced conformational control
- Combining computational screening and functional validation to rapidly discover potent molecular glue candidates and accelerate translation into cellular and in vivo models
12:30 pm Lunch Break & Networking
Beyond Oncology: Molecular Glues Across New Therapeutic Frontiers to Unlock Opportunities in High-Unmet-Need Diseases
1:30 pm Harnessing Non-Degrading Molecular Glues to Rewire Immune Signalling & Expand Therapeutic Opportunities
- Leveraging non-degrading molecular glues to induce productive protein-protein interactions, expanding the induced proximity toolkit beyond targeted protein degradation
- Reprogramming immune signalling pathways through proximity-driven modulation of transcription factors and other immunological regulators, unlocking new therapeutic opportunities in immune-mediated diseases
- Advancing orally available small-molecule therapies that deliver biologics-like effects through targeted protein interaction control, broadening the clinical potential of molecular glues
2:00 pm Rational Discovery of Molecular Glues and Proximity-Based Therapeutics Across Diverse Disease Areas
- Demonstrating how rational discovery approaches are enabling the identification of molecular glues and proximity-based therapeutics for targets and indications beyond oncology
- Exploring modality-agnostic strategies spanning molecular glues, PROTACs, and antibody-conjugated degraders to unlock new opportunities across autoimmune and neurological diseases
- Sharing lessons from advancing non-oncology degradation programs to accelerate the translation of induced proximity therapeutics into diverse disease areas
2:30 pm Panel Discussion: Deploying Molecular Glues to Tackle Neurodegeneration’s Toughest Targets
- How can molecular glues be leveraged to target pathogenic protein aggregates and drive the selective clearance of disease-causing proteins across Alzheimer’s, Parkinson’s, and Huntington’s disease?
- What strategies are proving most effective for engineering brain-penetrant molecular glues that improve CNS exposure and target engagement while enhancing the translational potential of neurodegeneration programs?
- How can target engagement be most effectively validated in disease-relevant neuronal models to better understand therapeutic impact and de-risk progression into clinical development?
3:00 pm Afternoon Break & Networking
Decoding Ternary Complex Formation: Predicting Productive Ternary Complexes at Scale
3:30 pm Engineering Prospective, Rational Design of Molecular Glues
- Introducing our AI models Leopard, Puffin, Gecko and Octopus
- Applying the Ternary Platform to ‘undruggable’ targets
- GRIPs: small molecule RIPTACs
4:00 pm Proximal and Productive: A Transferable Free-Energy Based Conformational-Ensemble Engine for Ternary-Complex and Molecular Glue Discovery
- Mapping the free-energy based conformational ensemble for protein-protein interface rather than a single crystallographic pose enables ligandability of a pocket as a measurable quantity with a known free energy.
- Filtering the free-energy landscape for a productive ubiquitin transfer, i.e. lysine reach, residence time and turnover, identifies pockets with biological functional outcomes, not just a protein-protein glue.
- Ensemble-scale pharmacophore-based and generative AI based targeted virtual screening enables the discovery of functional molecular glues