From Library to Lead: Uncovering Unexpected Cooperativity in Molecular Glue Discovery
11:30 am - Wednesday 27th January 2027
- Applying DNA-encoded libraries (DELs) to interrogate vast chemical space for rare and productive glue interactions, unlocking novel starting points against challenging targets
- Uncovering unexpected mechanisms of cooperativity in ternary complex formation, leading to higher quality hits and a more efficient discovery process
- Implementing a comprehensive downstream validation workflow to rapidly confirm on-target mechanism and accelerate the progression of validated hits toward lead optimization
