Mat Sowa
Vice President, Lead Discovery C4 Therapeutics Inc
Mat Sowa is Vice President of Lead Discovery at C4 Therapeutics. A multidisciplinary scientist and leader in discovery sciences, his work focuses on protein-protein interactions, proteomics, structural biology, and chemical biology. His research has driven important advances in understanding cellular signaling and protein function, resulting in more than 40 peer-reviewed publications in leading journals including Cell, Nature, Molecular Cell, and Nature Cell Biology.
Seminars
Wednesday 27th January 2027
From Library to Lead: Uncovering Unexpected Cooperativity in Molecular Glue Discovery
11:30 am
- Applying DNA-encoded libraries (DELs) to interrogate vast chemical space for rare and productive glue interactions, unlocking novel starting points against challenging targets
- Uncovering unexpected mechanisms of cooperativity in ternary complex formation, leading to higher quality hits and a more efficient discovery process
- Implementing a comprehensive downstream validation workflow to rapidly confirm on-target mechanism and accelerate the progression of validated hits toward lead optimization
