Finding the Right Hits Faster: Designing Screening & Prioritization Cascades for Molecular Glue Discovery

For many organizations, identifying a molecular glue hit is only the first hurdle.

Determining whether that hit is mechanistically meaningful, clinically relevant, and worth

the significant investment required for optimization remains one of the field’s greatest

challenges. Researchers increasingly recognize that no single screening technology is

sufficient, leading to growing adoption of DELs, functional screening, in-cell discovery

platforms, proteomics, and biophysical characterization methods. This workshop will

examine how to construct robust screening and profiling cascades that distinguish

genuine opportunities from false positives, establish confidence in mechanism of action,

and support more informed go/no-go decisions throughout molecular glue discovery.

Join this workshop to:

• Compare DEL, functional, cellular, proteomic, and next-generation screening approaches to identify productive induced-proximity events and expand discovery beyond traditional cereblon-based degradation
• Design multi-parameter profiling cascades that evaluate cooperativity, selectivity, mechanism of action, and biological relevance using biophysical tools, proteomics, and disease-relevant cellular models

Speakers: