Yuhong Du
Associate Professor Emory University
Yuhong Du is Associate Professor of Pharmacology and Chemical Biology at Emory University School of Medicine and Associate Director of Assay Development and High-Throughput Screening at the Emory Chemical Biology Discovery Center. An expert in chemical biology and drug discovery, she has pioneered innovative high-throughput and ultra-high-throughput screening technologies for identifying novel therapeutic leads. As a founding member of the Emory Chemical Biology Discovery Center, she helped establish its advanced screening infrastructure and has contributed to numerous discoveries across oncology, neurodegeneration, infectious disease, and molecular glue therapeutics.
Seminars
For many organizations, identifying a molecular glue hit is only the first hurdle. Determining whether that hit is mechanistically meaningful, clinically relevant, and worth the significant investment required for optimization remains one of the field’s greatest challenges. Researchers increasingly recognize that no single screening technology is sufficient, leading to growing adoption of DELs, functional screening, in-cell discovery platforms, proteomics, and biophysical characterization methods. This workshop will examine how to construct robust screening and profiling cascades that distinguish genuine opportunities from false positives, establish confidence in mechanism of action, and support more informed go/no-go decisions throughout molecular glue discovery.
Join this workshop to:
- Compare DEL, functional, cellular, proteomic, and next-generation screening approaches to identify productive induced-proximity events and expand discovery beyond traditional cereblon-based degradation
- Design multi-parameter profiling cascades that evaluate cooperativity, selectivity, mechanism of action, and biological relevance using biophysical tools, proteomics, and disease-relevant cellular models
