Expanding Molecular Glue Discovery Beyond Degradation: Identifying Transcription Factor Inhibitors Through Conformational Trapping

• Overcoming the challenge of drugging transcription factors by developing a functional E. coli screening platform to identify molecular glues that trap proteins in inactive conformations
• Moving beyond degradation by selectively preventing transcription factor DNA binding and suppressing downstream gene expression through induced conformational control
• Combining computational screening and functional validation to rapidly discover potent molecular glue candidates and accelerate translation into cellular and in vivo models

Speakers:

Gali Prag

Co-Founder & Board Member

Coltac Therapeutics