Allostery Meets Induced Proximity: Creating New Pharmacological States with Non-Degrading Molecular Glues

• Leveraging molecular glues and allosteric modulators to selectively reprogram kinase signalling networks, enhancing target inhibition and unlocking synergistic therapeutic effects across oncogenic pathways
• Harnessing molecular glues to stabilize productive protein-protein interactions and activate selective cellular quality control mechanisms, expanding the biological outcomes achievable through induced proximity
• Exploring how induced protein interactions can reshape allosteric pharmacology and create new functional protein states, revealing therapeutic opportunities beyond conventional inhibition and degradation

Speakers:

Evris Gavathiotis

Professor of Biochemistry, Medicine, and Oncology

Albert Einstein College of Medicine