Evris Gavathiotis
Professor of Biochemistry, Medicine, and Oncology Albert Einstein College of Medicine
Seminars
Thursday 28th January 2027
Allostery Meets Induced Proximity: Creating New Pharmacological States with Non-Degrading Molecular Glues
9:30 am
- Leveraging molecular glues and allosteric modulators to selectively reprogram kinase signalling networks, enhancing target inhibition and unlocking synergistic therapeutic effects across oncogenic pathways
- Harnessing molecular glues to stabilize productive protein-protein interactions and activate selective cellular quality control mechanisms, expanding the biological outcomes achievable through induced proximity
- Exploring how induced protein interactions can reshape allosteric pharmacology and create new functional protein states, revealing therapeutic opportunities beyond conventional inhibition and degradation
Thursday 28th January 2027
Panel Discussion: Deploying Molecular Glues to Tackle Neurodegeneration’s Toughest Targets
2:00 pm
- How can molecular glues be leveraged to target pathogenic protein aggregates and drive the selective clearance of disease-causing proteins across Alzheimer’s, Parkinson’s, and Huntington’s disease?
- What strategies are proving most effective for engineering brain-penetrant molecular glues that improve CNS exposure and target engagement while enhancing the translational potential of neurodegeneration programs?
- How can target engagement be most effectively validated in disease-relevant neuronal models to better understand therapeutic impact and de-risk progression into clinical development?
