8:00 am
Registration & Morning Networking Coffee
8:50 am Chair’s Opening Remarks
Tackling the Rationale Design of Next-Generation Molecular Glues to Screen for & Validate High Value Clinical Candidates
9:00 am Panel Discussion: Envisioning the Rational Design of Molecular Glues to Generate Clinically Relevant Candidates with High Value Therapeutic Applications
10:00 am Accelerating Molecular Glue Discovery through AI/ML & Computation
10:30 am Morning Break & Speed Networking
Synopsis
Our speed networking is the ideal opportunity to get face-to-face time with many of the brightest minds working in the field & introduce yourself to the attendees that you would like to have more in-depth conversations with. Benchmark against industry leaders & establish meaningful business relationships to pursue for the rest of the conference & beyond.
Optimizing Molecular Glues Towards Cooperativity Through Mapping the Protein-Protein Interface Composition
11:30 am Interrogating the Protein-Protein Interface to Leverage the Bottom-Up Development of Molecule Glues Irrespective of a Defined Target Protein
12:00 pm Enabling insights into molecular glue MoA toward design of potent and selective CK1a degraders
12:30 pm Utilizing Ternary Complex Structures to Streamline Molecular Glue Development
Synopsis
- Using structural biology technologies to uncover the properties of ternary complexes and identify glycine-containing degrons and novel degrons
- Understanding how to leverage ternary complex dynamics to direct drug discovery
- Using data processing packages to streamline the manipulation of complex structural data