Jonathan Solomon
Seminars
Wednesday 27th January 2027
Beyond Cereblon: A Target-Directed Approach to Molecular Glue Discovery
2:00 pm
- Overcoming the field’s reliance on Cereblon-first discovery by developing a target-directed strategy that expands molecular glue opportunities across new biological pathways
- Matching targets to the most suitable ligases through a mutagenesis-based approach, enabling discovery efforts beyond established Cereblon biology
- Building a more systematic framework for molecular glue discovery to uncover novel target-ligase pairings, broaden the druggable proteome, and accelerate first-in-class therapeutic opportunities
Wednesday 27th January 2027
Panel Discussion: De-Risking Molecular Glue Development: What Does It Take to Build a Clinically and Commercially Successful Programme?
4:00 pm
- How can developers integrate proteomics, mechanistic biology, translational biomarkers, and emerging clinical data to identify safety liabilities early and improve confidence in candidate selection?
- What are the most important scientific, clinical, regulatory, and commercial risks facing molecular glue programmes today, and how should biotech leaders, investors, and drug developers assess them when making development and funding decisions?
- As more molecular glues advance toward the clinic, what frameworks are needed to evaluate off-target effects, long-term biological consequences, and programme differentiation to enable informed go/no-go, partnering, and investment decisions?
