Dalia Barsyte Lovejoy
Principal Investigator University of Toronto
Seminars
Thursday 29th January 2026
Harnessing Novel E3 Ligases to Unlock New Opportunities in Molecular Glue Drug Discovery
10:00 am
- Leveraging a large portfolio of novel E3 ligases in diverse screening campaigns (traditional screening, DEL, ML-based approaches, and ASMS) to expand the landscape of glue discovery
- Identifying hits that engage substrate recognition components of E3 ligases, supported by structural insights and mechanistic validation
- Highlighting case studies, including FBXO22 and a deubiquitinase–E3 ligase axis, as emerging examples of potential molecular glue mechanisms with translational relevance
