Dalia Barsyte Lovejoy
Principal Investigator University of Toronto
Dr. Barsyte-Lovejoy is an Associate Professor and Principal Investigator at the Structural Genomics Consortium, University of Toronto. She received a PhD in molecular biology from the University of Manchester, UK, and postdoctoral training at the Ontario Cancer Institute. Dr. Barsyte-Lovejoy’s research focuses on targeting the epigenetic mechanisms and signaling in cancer. Her group designs target engagement, PPI assays and employs proteomics and genomics analysis to identify novel cancer targeting agents.
Seminars
Thursday 29th January 2026
Harnessing Novel E3 Ligases to Unlock New Opportunities in Molecular Glue Drug Discovery
10:00 am
- Leveraging a large portfolio of novel E3 ligases in diverse screening campaigns (traditional screening, DEL, ML-based approaches, and ASMS) to expand the landscape of glue discovery
- Identifying hits that engage substrate recognition components of E3 ligases, supported by structural insights and mechanistic validation
- Highlighting case studies, including FBXO22 and a deubiquitinase–E3 ligase axis, as emerging examples of potential molecular glue mechanisms with translational relevance
