Asghar Razavi
Director of Molecular Modeling & Design Fathom Therapeutics
Asghar Razavi is Director of Molecular Modeling and Design at Fathom Therapeutics, where he leads computational chemistry, molecular modeling, and structure-based drug design efforts to advance next-generation cancer therapeutics. A computational chemist and biophysicist by training, he specializes in applying molecular simulations, biophysical modeling, and data-driven approaches to target discovery and drug optimization. Prior to joining Fathom Therapeutics, he completed his PhD in computational chemistry and biophysics at Temple University and his postdoctoral training at Weill
Cornell Medical College.
Seminars
Thursday 28th January 2027
Proximal and Productive: A Transferable Free-Energy Based Conformational-Ensemble Engine for Ternary-Complex and Molecular Glue Discovery
4:00 pm
- Mapping the free-energy based conformational ensemble for protein-protein interface rather than a single crystallographic pose enables ligandability of a pocket as a measurable quantity with a known free energy.
- Filtering the free-energy landscape for a productive ubiquitin transfer, i.e. lysine reach, residence time and turnover, identifies pockets with biological functional outcomes, not just a protein-protein glue.
- Ensemble-scale pharmacophore-based and generative AI based targeted virtual screening enables the discovery of functional molecular glues
