Rewiring Gene Expression with Synthetic Gene Regulators to Access Previously Undruggable Biology

• Harnessing synthetic gene regulators to induce targeted DNA-protein interactions and reprogram gene expression, expanding induced-proximity therapeutics beyond protein degradation
• Developing modular transcription-targeting platforms to selectively control disease-driving gene networks, unlocking therapeutic opportunities against previously intractable targets
• Translating synthetic gene regulation from foundational discovery to clinical development through scalable design principles and emerging therapeutic programmes, broadening the future scope of induced-proximity medicine

Speakers:

Aseem Ansari

Chair of the Department of Chemical Biology and Therapeutics

St. Jude Children's Research Hospital