Beyond Cereblon: A Target-Directed Approach to Molecular Glue Discovery

2:00 pm - Wednesday 27th January 2027

Overcoming the field’s reliance on Cereblon-first discovery by developing a target-directed strategy that expands molecular glue opportunities across new biological pathways
Matching targets to the most suitable ligases through a mutagenesis-based approach, enabling discovery efforts beyond established Cereblon biology
Building a more systematic framework for molecular glue discovery to uncover novel target-ligase pairings, broaden the druggable proteome, and accelerate first-in-class therapeutic opportunities