Activating the Undruggable with neoCMG101 to Expand Therapeutic Opportunities Beyond Degradation
11:30 am - Thursday 28th January 2027
- Developing neoCMG101 as a molecular glue activator to drive targeted protein function rather than protein destruction, demonstrating the potential of glue-mediated activation strategies
- Elucidating the structural and mechanistic basis of activation to understand how induced proximity can reprogram cellular signalling, providing a framework for future activator-glue discovery
- Translating activator biology into therapeutic opportunity to address disease drivers beyond the reach of conventional degraders, broadening the molecular glue modality.