The Convergence of Genetic and Chemical Glues: Programming Protein Interaction Networks for Precision Therapeutics

• Introducing the concept of genetic glues—disease-associated mutations that rewire protein interaction networks—to establish a unified framework linking genetic perturbations with chemical glue pharmacology.
• Demonstrating how mutation-directed and neo-cysteine molecular glues selectively reprogram disease-specific protein interaction networks, enabling therapeutic activation of previously undruggable tumor suppressors.
• Presenting a next-generation discovery strategy that integrates cancer genetics, protein interaction network biology, and induced-proximity chemistry to expand molecular glue therapeutics beyond targeted protein degradation.

Speakers:

Xiulei Mo

Associate Professor

Emory University