Bradlee Heckmann

Company: ASHA therapeutics

Job title: Co-founder & Chief Scientific Officer

Seminars:

Utilizing PRISM™ for Intramolecular Glue Design & Optimization to Develop Small Molecules with Reduced Toxicity 2:00 pm

How to identify unique binding pockets in SARM1 as sites for an intramolecular glue Predicting toxicology and PKPD of molecular glues with PRISM to streamline development of glues Validating the PRISM platform with experimental results to continue predicting molecular glue properties New Data New CompanyRead more

day: Conference Day Two

Panel Discussion: Spearheading Structure-Based Rational Design to Develop More Effective Molecular Glues 3:45 pm

What are the structural considerations between ligases, target proteins and molecular glues in rational design? How to overcome the difficulties in turning protein models from crystal structures to dynamic models What information do the different computational models give about the ternary complexes and how can this be leveraged in molecular glue design? New CompaniesRead more

day: Conference Day One