Driving Forward Lead Optimization of Molecular Glues with Enhanced Potency for Better Degraders
Time: 1:01 pm
day: Pre-Conference Day
Details:
Once the glue hit has been identified, the lead optimization of the selected small molecule is required for the development of an active drug. The improvements needed for potential glues to be more specific for their target ligase and protein of interest will be discussed here:
- What are the differences and similarities for optimizing a target-first and molecule-first glue identification approaches to develop effective degraders?
- How can we enhance binding for glues and E3 ligases to have greater induced PPI?
- Do all molecular glues require optimization in the same way for ligases?
