Mikolaj Slabicki
Principal Investigator Massachusetts General Hospital
Mikołaj Słabicki, Ph.D., is a Principal Investigator at the MGH Krantz Family Center for Cancer Research, an Assistant Professor of Medicine at Harvard Medical School, and an Associate Member at the Broad Institute of MIT and Harvard. His research focuses on expanding the druggable proteome by leveraging functional genomics, high-throughput screening, chemical biology, cell biology, and biochemical techniques. His team aims to discover and characterize new molecular glue degraders and explore novel mechanisms of targeted protein degradation.
Seminars
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- Exploring how small molecules such as BI-3802 induce BCL6 polymerization, leading to target sequestration and subsequent proteasomal degradation
- Harnessing chemically controlled on/off oligomerization switches for synthetic biology applications
- BTB-domain polymerization represents a broader mechanism across ZBTB transcription factors, enhancing chromatin occupancy and gene repression
