Mikolaj Slabicki

Principal Investigator Massachusetts General Hospital

Mikołaj Słabicki, Ph.D., is a Principal Investigator at the MGH Krantz Family Center for Cancer Research, an Assistant Professor of Medicine at Harvard Medical School, and an Associate Member at the Broad Institute of MIT and Harvard. His research focuses on expanding the druggable proteome by leveraging functional genomics, high-throughput screening, chemical biology, cell biology, and biochemical techniques. His team aims to discover and characterize new molecular glue degraders and explore novel mechanisms of targeted protein degradation.

Seminars

Wednesday 28th January 2026
Morning Break & Speed Networking
10:30 am

Join our speed networking session tailored for Molecular Glue professionals, like yourself, to connect with fellow industry peers to facilitate rapid yet meaningful exchanges of insights and expertise. Elevate your networking experience during this session designed for impactful connections within the space.

Wednesday 28th January 2026
Drug-Induced Polymerization as a Novel Mechanism for Target Modulation & Therapeutic Control
10:00 am
  • Exploring how small molecules such as BI-3802 induce BCL6 polymerization, leading to target sequestration and subsequent proteasomal degradation
  • Harnessing chemically controlled on/off oligomerization switches for synthetic biology applications
  • BTB-domain polymerization represents a broader mechanism across ZBTB transcription factors, enhancing chromatin occupancy and gene repression
Headshot - Mikolaj Slabicki