Jonathan Solomon
Director Novartis AG
Seminars
Wednesday 28th January 2026
Beyond the Beta Turn: A Novel Structural Motif Bound by a CRBN Glue Degrader
11:30 am
- A screen identified CRBN glues for TBK1
- Structure of the ternary CRBN-glue-TBK1 complex reveals a unique binding mode
- These TBK1 glues are selective over the closely related IKKe kinase
