RapaGlueTM Platform – A Novel Non-Degrading Molecular Glue Modality for Unlocking the Hard to Drug Proteome
- Discover how RapaGlues™, a novel class of non-degrading macrocyclic peptide molecular glues, achieve potent, selective target engagement with long residence times, aided by AI/ML-driven design and structural insights
- Learn from case studies using DEL screening and X-ray crystallography that reveal unique binding modes, cryptic pocket engagement, and successful inhibition of challenging targets including transcription factors, SLCs, and TNF-alpha pathway proteins
- Explore strategies to optimize permeability, stability, and oral bioavailability of macrocyclic glues, expanding drug discovery opportunities across diverse and hardto-drug protein classes