Platform for the Discovery of Molecular Glues
- Lighting up molecular glue biology in real time – we developed a NanoBRET-powered high-throughput platform that directly visualizes E3 ligase–substrate interactions in live cells, transforming molecular glue discovery from serendipity to systematic science
- From mechanism to molecules – by capturing dynamic CRBN–CUL4A and DCAF15–CUL4A assemblies with sensitive NanoBRET proximity assays, this platform delivers both mechanistic insight and a scalable engine to uncover new degraders across the CRL family
- Expanding the degradable proteome – applying this approach, we identified novel glue candidates and validated CMC2 as a DCAF15-recruiting substrate for proof-of-concept degradation, demonstrating a powerful strategy to accelerate glue discovery and guide next-generation targeted protein degradation therapies