Harnessing Novel Molecular Glue Degraders to Target K-Ras Mutants & Overcome Resistance Pathways

  • Engaging a novel ligase for targeted degradation to selectively degrade mutant K-Ras while sparing the wild-type protein
  • Dual-target effect via co-degradation of Seraph, addressing the major resistance pathway in K-Ras-driven cancers and creating a unique therapeutic opportunity
  • Structural insights into ternary complex formation, revealing how the molecular glue stabilizes interactions between the ligase and target proteins, guiding next-generation degrader design