Drug-Induced Polymerization as a Novel Mechanism for Target Modulation & Therapeutic Control

• Exploring how small molecules such as BI-3802 induce BCL6 polymerization, leading to target sequestration and subsequent proteasomal degradation
• Harnessing chemically controlled on/off oligomerization switches for synthetic biology applications
• BTB-domain polymerization represents a broader mechanism across ZBTB transcription factors, enhancing chromatin occupancy and gene repression

Speakers:

Mikolaj Slabicki

Principal Investigator

Massachusetts General Hospital