Drug-Induced Polymerization as a Novel Mechanism for Target Modulation & Therapeutic Control

  • Exploring how small molecules such as BI-3802 induce BCL6 polymerization, leading to target sequestration and subsequent proteasomal degradation
  • Harnessing chemically controlled on/off oligomerization switches for synthetic biology applications
  • BTB-domain polymerization represents a broader mechanism across ZBTB transcription factors, enhancing chromatin occupancy and gene repression