Biology-First Discovery of Non-Degrading Molecular Glues Targeting E2 Enzymes for Neurodegeneration

  • Leveraging AI-driven biology discovery to identify ubiquitin-conjugating enzymes (E2s) as novel therapeutic target
  • Demonstrating a unique mechanism of action by locking ubiquitin to E2 enzymes, preventing discharge, inhibiting enzyme function, and triggering autophagy to clear mutant huntingtin
  • Advancing lead optimization efforts with the goal of progressing to animal proof-ofconcept studies for neurodegenerative proteinopathies