Beyond the Beta Turn: A Novel Structural Motif Bound by a CRBN Glue Degrader

• A screen identified CRBN glues for TBK1
• Structure of the ternary CRBN-glue-TBK1 complex reveals a unique binding mode
• These TBK1 glues are selective over the closely related IKKe kinase

Speakers:

Jonathan Solomon

Director

Novartis AG